Don Tillman, a professor of genetics, sets up a project designed to find him the perfect wife, starting with a questionnaire that has to be adjusted a little as he goes along. Then he meets Rosie, who is everything he's not looking for in a wife, but she ends up his friend as he helps her try and find her biological father.

Feeling cast off when her best friend outgrows their shared love for a favorite celebrity, Cath, a dedicated fan-fiction writer, struggles to survive on her own in her first year of college while avoiding a surly roommate, bonding with a handsome classmate who only wants to talk about words and worrying about her fragile father.